Use LC-MS to Confirm Unknown Degradants in Advanced Stability Studies
Understanding the Tip: Why LC-MS is critical for degradant identification: Liquid chromatography-mass spectrometry (LC-MS) combines the separation power of HPLC with the structural elucidation capabilities of mass spectrometry. When unknown peaks appear in stability studies—especially at later time points or under accelerated conditions—traditional HPLC/UV methods may not be sufficient. LC-MS helps identify molecular weights, fragmentation…
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